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Preparation and preliminary evaluation of 4-[211At]astato-N-piperidinoethyl benzamide

โœ Scribed by Pradeep K. Garg; Christy S. John; Michael R. Zalutsky


Book ID
116172006
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
762 KB
Volume
22
Category
Article
ISSN
0969-8051

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## Abstract 4โ€Fluoroโ€__N__โ€{2โ€[4โ€(6โ€trifluoromethylpyridinโ€2โ€yl)piperazinโ€1โ€yl]ethyl}benzamide is a full 5โ€HT~1A~ agonist with high affinity (__pK__~__i__~=9.3), selectivity and a __c__ log __P__ of 3.045. The corresponding PET radioligand 4โ€[^18^F]fluoroโ€__N__โ€{2โ€[4โ€(6โ€trifluoromethylpyridinโ€2โ€yl)