Design, Synthesis and Biological Evaluation of 4-Amino- N -(4-aminophenyl)benzamide Analogues of Quinoline-Based SGI-1027 as Inhibitors of DNA Methylation
✍ Scribed by Rilova, Elodie; Erdmann, Alexandre; Gros, Christina; Masson, Véronique; Aussagues, Yannick; Poughon-Cassabois, Valérie; Rajavelu, Arumugam; Jeltsch, Albert; Menon, Yoann; Novosad, Natacha; Gregoire, Jean-Marc; Vispé, Stéphane; Schambel, Philippe; Ausseil, Fréderic; Sautel, François; Arimondo, Paola B.; Cantagrel, Frédéric
- Book ID
- 121729217
- Publisher
- John Wiley and Sons
- Year
- 2014
- Tongue
- English
- Weight
- 861 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1860-7179
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Nine novel nonclassical 2,4-diamino-6-methyl-5-thioarylsubstituted-7H-pyrrolo [2,3-d]pyrimidines 2-10 were synthesized as potential inhibitors of dihydrofolate reductase and as antitumor agents. The analogues contain various electron donating and electron withdrawing substituents on the phenylsulfan