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Preparation and in vivo binding of [11C]carazolol, a radiotracer for the beta-adrenergic receptor

✍ Scribed by Berridge, Marc S.; Cassidy, Emily H.; Terris, Andrew H.; Vesselle, Jean-Marc


Book ID
123194147
Publisher
Elsevier Science
Year
1992
Weight
736 KB
Volume
19
Category
Article
ISSN
0883-2897

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A method is described for the preparation of [11C]buprenorphine in high specific activity, based on the reaction of N-(de-cyclopropylmethyl)buprenorphine with "no carrier added" [1-11C]cyclopropanecarbonyl chloride followed by reduction with lithium aluminium hydride. The [1-11C]cyclopropanecarbonyl