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Preparation and in vitro evaluation of celecoxib-amino acid conjugates as a colon specific prodrug

โœ Scribed by Yonghyun Lee, Eun Hee Jung, Hyunjung Kim, Jeong-Hyun Yoon, Dae-Duk Kim, Yunjin Jung

Book ID
113112211
Publisher
Springer Netherlands
Year
2012
Tongue
English
Weight
252 KB
Volume
42
Category
Article
ISSN
2093-5552

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5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized and their properties as colon-speciยฎc prodrugs of 5aminosalicylic acid (5-ASA) were investigated employing rats as test animals. Incubation of 5-ASA-Asp and 5-ASA-Glu with the homogenates of ti