Preparation and evaluation of [F-18]-labeled 5-HT1A Agonist: 1-[2-(4-[F-18]Fluorobenzamido)-1-Ethyl]-4-(1,2,3,4-Tetrahydronaphth-1-YL)-Piperidine (FBP)
✍ Scribed by D. R. Hwang; K. Ngo; L. Savenkova; Y. Huang; N. Guo; Z. Zhu; M. Laruelle
- Book ID
- 112132870
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 166 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-2135
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## Abstract The feasibility of nucleophilic displacement of bromide in the 4‐bromopyrazole ring with [^18^F]fluoride has been demonstrated by the synthesis of two radiolabeled compounds: __N__‐(piperidin‐1‐yl)‐5‐(4‐methoxyphenyl)‐1‐(2‐chlorophenyl)‐4‐[^18^F]fluoro‐1__H__‐pyrazole‐3‐carboxamide, ([^
## Abstract The synthesis of 1‐(5‐chloro‐2‐{2‐[(2R)‐4‐(4‐[^18^F]fluorobenzyl)‐2‐methylpiperazin‐1‐yl]‐2‐oxoethoxy}phenyl)urea (**[^18^F]4**), a potent nonpeptide CCR1 antagonist, is described as a module‐assisted two‐step one‐pot procedure. The final product was obtained utilizing the reductive ami