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Preparation and evaluation of 2-substituted anthraquinones based on the anthracyclines

โœ Scribed by Bennett, Stephen; Sharples, Derek; Brown, Jeffrey R.


Book ID
121003779
Publisher
American Chemical Society
Year
1982
Tongue
English
Weight
698 KB
Volume
25
Category
Article
ISSN
0022-2623

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Friedel-Crafts acylation of 6-alkoxy-2-pyrones gives high yields of the 5-acyl-2-pyrones which undergo regioselective cycloaddition with various dienophiles. Adriamycin 1 and daunorubicin 1. are the anthracycline antitumor agents used most extensively in cancer chemotherapy today.2 Their use is limi