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Preparation and Conformational Properties of Benzylpenicilloyl-oligo-L-lysine Conjugates

✍ Scribed by Hanspeter Rolli; Immanuel F. Lüscher; Conrad H. Schneider; Claudio Toniolo; Gian Maria Bonora

Book ID
102252375
Publisher
John Wiley and Sons
Year
1982
Tongue
German
Weight
380 KB
Volume
65
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Selected oligo‐L‐lysine carriers and a poly‐L‐lysine were penicilloylated with benzylpenicillin. The resulting conjugates 2–6 were studied by IR. absorption in the solid state and circular dichroism measurements in solution. The IR. data demonstrate the lack of β‐structure formation even in medium‐sized peptides where such structures might be expected on the basis of previous studies on differently substituted oligo‐L‐lysines. Considerable proportions of right‐handed α ‐helical conformation are exhibited by the icosa‐L‐lysine and poly‐L‐lysine conjugates 5 and 6 in water and 2,2,2‐trifluoroethanol. Difficulties in obtaining fully penicilloylated conjugates are not related to the extent of α‐helical conformation in aqueous solution.

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