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Preparation and clinical evaluation of technetium-99m dimercaptosuccinic acid for tumour scintigraphy

✍ Scribed by Tsuneo Hirano; Katsumi Tomiyoshi; Ying Jian Zhang; Tsunehiro Ishida; Tomio Inoue; Keigo Endo

Publisher
Springer
Year
1994
Tongue
English
Weight
891 KB
Volume
21
Category
Article
ISSN
0340-6997

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✦ Synopsis

We describe a simple method of pentavalent technetium-99m dimercaptosuccinic acid [99nrFC(V)-DMSA] preparation for the imaging of medullary carcinoma of the thyroid using commercially available kits. 99nTc(V)-DMSA is available at high pH (approximately 7.5) by adding NaHCO3 solution in the presence of a small amout of reducing agent (SnC12). On the other hand, trivalent 99~l'c-DMSA [99~Tc(III)-DMSA] can be obtained at low pH (below 3) in the presence of an excess amount of reducing agent. In the clinical evaluation of a patient with a medullary carcinoma of the thyroid, only 99mTc(V)-DMSA revealed an area of intense accumulation.

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