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Preparation and biological evaluation of technetium-99m-phenylethylamine complexes

✍ Scribed by Arturo A. Vitale; María Ana Calviño; Carina C. Ferrari; Adriana E. Stahl; Alicia B. Pomilio

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
498 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Biological and chemical characteristics of ^99m^Tc‐phenethylamines complexes are presented. 2‐(4,5‐Dimethoxy‐2‐nitrophenyl)ethylamine, 2‐(3,4‐dimethoxyphenyl)ethylamine and 2‐(2‐amino‐4,5‐dimethoxyphenyl)‐ethylamine were used as ligands. A preliminary evaluation of these ^99m^Tc‐complexes as dopamine receptor radioligands was also performed. Net charges at each atom were also calculated by a semiempirical ZINDO/1 method for comparison of free ligands' parameters with those of the respective technetium‐complexes.

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