A convergent synthesis of an LTD4 antago
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Adam W. Sledeski; Michael K. O'Brien; Larry K. Truesdale
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Article
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1997
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Elsevier Science
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French
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An efficient, convergent synthesis of an LTD 4 antagonist, RG12525 (1) has been achieved through the alkylation of the (2-quinolinylmethoxy)phenol (2) with either a triphenylmethyl protected tetrazole synthon (4a) or with a tetrahydropyranyl derivative (4b). Preparation of synthons 4a and 4b, as wel