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Preparation and characterization of polymorphs for an LTD4 antagonist, RG 12525

โœ Scribed by Robert A. Carlton; Thomas J. Difeo; Tory H. Powner; Ivan Santos; Michael D. Thompson


Book ID
109388409
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
211 KB
Volume
85
Category
Article
ISSN
0022-3549

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๐Ÿ“œ SIMILAR VOLUMES


A convergent synthesis of an LTD4 antago
โœ Adam W. Sledeski; Michael K. O'Brien; Larry K. Truesdale ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 206 KB

An efficient, convergent synthesis of an LTD 4 antagonist, RG12525 (1) has been achieved through the alkylation of the (2-quinolinylmethoxy)phenol (2) with either a triphenylmethyl protected tetrazole synthon (4a) or with a tetrahydropyranyl derivative (4b). Preparation of synthons 4a and 4b, as wel