𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Preparation and Characterization of Novel Quaternized Cellulose Nanoparticles as Protein Carriers

✍ Scribed by Yongbo Song; Jinping Zhou; Qian Li; Yi Guo; Lina Zhang

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
262 KB
Volume
9
Category
Article
ISSN
1616-5187

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Quaternized cellulose (QC) nanoparticles were prepared in distilled water by ionic crosslinking of QC with sodium tripolyphosphate (TPP) for the first time. BSA as a model protein drug was used to investigate the loading and release features of the nanoparticles. The results indicated that QC nanoparticles had high loading efficiency and capacity for BSA. The in vitro BSA release of the QC nanoparticles displayed a burst effect in the first 2 h and then a slow continuous release. Nanoparticles with a higher DS of QC showed a decrease in particle size, an increase in zeta potential, a higher loading efficiency and a slower drug‐release profile. These studies demonstrated that QC nanoparticles are potential protein carriers, and that their physicochemical properties and release profile could be easily adjusted.

magnified image

📜 SIMILAR VOLUMES

Novel hydrophilic chitosan-polyethylene
Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers
✍ P. Calvo; C. Remuñán-López; J. L. Vila-Jato; M. J. Alonso 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 185 KB 👁 1 views

Hydrophilic nanoparticulate carriers have important potential applications for the administration of therapeutic molecules. The recently developed hydrophobic-hydrophilic carriers require the use of organic solvents for their preparation and have a limited protein-loading capacity. To address these

Preparation and characterization of inul
Preparation and characterization of inulin ester microspheres as drug carriers
✍ Xiao Yu Wu; Ping I. Lee 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 234 KB 👁 2 views

Acetylated and succinoylated inulin were synthesized by reacting inulin with acetic anhydride and succinic anhydride. The modified inulin was characterized by FTIR, NMR, and potentiometric titration. The compositional dependence of their properties, such as solubility, pKa, and melting point, was in

Enzyme-based hydrogels containing dextra
Enzyme-based hydrogels containing dextran as drug delivery carriers: Preparation, characterization, and protein release
✍ Junying Lai; Rui Fang; Li-Qun Wang; Kehua Tu; Changsheng Zhao; Xiaoqian Qian; Sh 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 690 KB

## Abstract Novel enzyme‐based hydrogels for drug delivery were prepared by combining dextran with 5,5′‐azodisalicylic acid using isophorone diisocyanate as the crosslinking agent. The structure of the resultant dextran/5,5′‐azodisalicylic acid hydrogels was determined by infrared spectra, and the

Preparation, characterization, and prote
Preparation, characterization, and protein loading properties of N-acyl chitosan nanoparticles
✍ Youngjin Cho; Jun Tae Kim; Hyun Jin Park 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 621 KB

## Abstract Various __N__‐acyl chitosans with propionyl‐, hexanoyl‐, nonanoyl‐, lauroyl‐, pentadecanoyl‐, and stearoyl‐groups were synthesized and self‐aggregated __N__‐acyl chitosan nanoparticles (CSNPs) were prepared by sonication. By the modification with __N__‐acyl groups, CSNPs increased their

Preparation and characterization of silv
Preparation and characterization of silver nanoparticles with dendrimers as templates
✍ Lei Jin; Shi-Ping Yang; Hui-Xia Wu; Wei-Wei Huang; Qi-Wei Tian 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 480 KB 👁 1 views

## Abstract In this study, crystal silver nanoparticle clusters, prepared by the reduction of AgNO~3~ in the presence of third‐to‐sixth‐generation dendrimers with a trimesyl core, were characterized with ultraviolet–visible spectroscopy, transmission electron microscopy, and energy‐dispersive X‐ray