Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres encapsulated with hydrophilic drugs have been successfully prepared by a solidin-oil-in-water (s/o/w) solvent evaporation method in the presence of anionic surfactants, sodium dodecyl sulfate (SDS), and dioctyl sodium sulfosuccinat
Preparation and characterization of negatively charged poly(lactic-co-glycolic acid) microspheres
✍ Scribed by Xu, Qingguo (author);Crossley, Alison (author);Czernuszka, Jan (author)
- Publisher
- John Wiley and Sons Inc.
- Year
- 2009
- Tongue
- English
- Weight
- 303 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract We developed poly(propylene fumarate)/poly(lactic‐__co__‐glycolic acid) (PPF/PLGA) blend microspheres and investigated the effects of various processing parameters on the characteristics of these microspheres. The advantage of these blend microspheres is that the carbon–carbon double bo
The development of a stable sustained-release formulation of recombinant human nerve growth factor (rhNGF) for the treatment of neuronal diseases is described. The protein was encapsulated into poly(lactic-co-glycolic) acid (PLGA) microspheres using a spray freeze drying technique. Liquid nitrogen a
Poly(lactic acid) (PLA) and poly(lactic/glycolic acid) copolymers (PLGA) are biodegradable drug carriers of great importance, although successful pharmaceutical application requires adjustment of the surface properties of the polymeric drug delivery system to be compatible with the biological enviro
## Abstract The immune response induced in mice by β‐galactosidase (β‐gal) adsorbed or encapsulated on poly(lactic acid) (PLA) and poly(lactic‐__co__‐glycolic acid) (PLGA) microspheres was investigated. The encapsulated protein elicited higher antibody response than the protein adsorbed on the micr
## Abstract A novel PLA‐based polymer containing reactive pendent ketone or hydroxyl groups was synthesized by the copolymerization of L‐lactide with __ε__‐caprolactone‐based monomers. The polymer was activated with NPC, resulting in an amine‐reactive polymer which was then cast into thin polymeric