𝔖 Bobbio Scriptorium
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Conjugation of Bioactive Groups to Poly(lactic acid) and Poly[(lactic acid)-co-(glycolic acid)] Films

✍ Scribed by Emma L. Prime; Justin J. Cooper-White; Greg G. Qiao

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
219 KB
Volume
7
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

A novel PLA‐based polymer containing reactive pendent ketone or hydroxyl groups was synthesized by the copolymerization of L‐lactide with ε‐caprolactone‐based monomers. The polymer was activated with NPC, resulting in an amine‐reactive polymer which was then cast into thin polymeric films, either alone or as part of a blend with PLGA, before immersion into a solution of the cell adhesion peptide GRGDS in PBS buffer allowed for conjugation of GRGDS to the film surfaces. Subsequent 3T3 fibroblast cell adhesion studies demonstrated an increase in cellular adhesion and spreading over films cast from unmodified PLGA. Hence the new polymer can be used to obtain covalent linkage of amine‐containing molecules to polymer surfaces.

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