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Preparation and assessment of glutaraldehyde-crosslinked collagen–chitosan hydrogels for adipose tissue engineering

✍ Scribed by Xuemei Wu; Lindsay Black; Guido Santacana-Laffitte; Charles W. Patrick; Jr.

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
485 KB
Volume
81A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

A portfolio of crosslinked chitosan:collagen blends was prepared, and their microarchitecture and water binding capacity were studied to investigate their application for adipose tissue engineering. Glutaraldehyde (GA) concentration had little effect on scaffold morphology or water binding capacity. However, the processing freezing temperature prior to lyophilization affected both. In vitro cytocompatibility of preadipocytes (PAs) was assessed for a candidate collagen:chitosan blend using two assays. Results confirm the viability of PAs on GA‐crosslinked collagen:chitosan scaffolds. A rat subcutaneous pocket assay was employed to assess PA‐seeded scaffolds in vivo. Animal tests proved that PA‐seeded scaffolds were biocompatible, could induce vascularization, and form adipose tissue. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006

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