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Preoperative radiotherapy and bevacizumab for angiosarcoma of the head and neck: Two case studies

✍ Scribed by Bridget F. Koontz; Edward F. Miles; Mary Ann D. Rubio; John F. Madden; Samuel R. Fisher; Richard L. Scher; David M. Brizel

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 219 KB
Volume: 30
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.20674

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✦ Synopsis

Abstract

Background.

Angiosarcoma of the face is a vascular tumor with poor local control and short median survival despite standard treatment. Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth factor (VEGF), which can inhibit tumor growth. It is synergistic with radiotherapy in gastrointestinal malignancies. Given the vascular nature of angiosarcoma and the need for better treatment of this disease, we investigated the concurrent use of bevacizumab with preoperative radiotherapy for head and neck angiosarcoma.

Methods.

Two patients diagnosed with angiosarcoma of the nose were treated preoperatively with bevacizumab (5–10 mg/kg) and concurrent radiotherapy (50 Gy), followed by resection of the tumor bed.

Results.

Both patients had a complete pathologic response with no residual disease. Neither has developed recurrence, with follow‐up of 8.5 months and 2.1 years.

Conclusions.

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