Preneoplastic transformation of rat tracheal epithelial cells by ozone
β Scribed by David G. Thomassen; Jack R. Harkema; Nicole D. Stephens; William C. Griffith
- Book ID
- 113207645
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 1018 KB
- Volume
- 109
- Category
- Article
- ISSN
- 0041-008X
No coin nor oath required. For personal study only.
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Five tumor-derived cell lines established from transformed rat tracheal epithelial (RTE) cells were examined for activated oncogenes using the NIH 3T3 assay, and the expression of 11 cellular oncogenes in the transformed cells was quantitated and compared with expression in normal RTE cells. DNA fro
## Abstract The purpose of our studies was to define abnormalities in the transforming growth factorβΞ² (TGFβΞ²) system of transformed rat tracheal epithelial (RTE) cells that might cause their abnormal growth behavior. We found that many, but not all, of the transformed cell lines were hyporesponsiv