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Prenatal Diagnosis of Hemoglobinopathies by DNA Analysis

✍ Scribed by HAIG H. KAZAZIAN JR.; CORINNE D. BOEHM; CAROL E. DOWLING


Book ID
118722371
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
814 KB
Volume
445
Category
Article
ISSN
0890-6564

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While analyzing 280 hemoglobinopathy kindreds with prescribed molecular tests, 3 unusual mutations were observed that required additional characterization. In the first case, the hypervariable region flanking the a-globin genes generated an intermediate length 8.2 kb qc-globin gene fragment on a Sou