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Prenatal detection of multiple fetal anomalies following inadvertent exposure to cyclophosphamide in the first trimester of pregnancy

✍ Scribed by Dario Paladini; Michele Vassallo; Maria Rosaria D'Armiento; Bruno Cianciaruso; Pasquale Martinelli

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 100 KB
Volume: 70
Category: Article
ISSN: 1542-0752
DOI: 10.1002/bdra.10147

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✦ Synopsis

Figure 1. Ultrasound findings and anatomical correlates. a: Severe biventricular hydrocephalus. b: Severe microretrognathia. c: Left hand, with only two digits of two phalanges each. d: Ectrodactyly of the right hand. e: Ectrodactyly of the left foot.

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Schwangerschafts Protein 1 (SP1), being a placental protein appearing in the maternal circulation early in pregnancy, has been investigated as a potential marker for Down syndrome in the first trimester. Our study compared SP1 levels in 15 pregnancies with a Down syndrome fetus and 97 matched contro