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Schwangerschafts protein 1 (SP1) adds little to the age-related detection of fetal Down syndrome in the first trimester of pregnancy

✍ Scribed by L. H. Kornman; L. P. Morssink; K. A. Ten Hoor; B. T. H. M. De Wolf; M. D. Kloosterman; J. R. Beekhuis; A. Mantingh

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 153 KB
Volume: 18
Category: Article
ISSN: 0197-3851
DOI: 10.1002/(sici)1097-0223(199810)18:10<1086::aid-pd393>3.0.co;2-8

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✦ Synopsis

Schwangerschafts Protein 1 (SP1), being a placental protein appearing in the maternal circulation early in pregnancy, has been investigated as a potential marker for Down syndrome in the first trimester. Our study compared SP1 levels in 15 pregnancies with a Down syndrome fetus and 97 matched controls. Although the median MoM in Down syndrome pregnancies (0•49) was lower than in controls, its use as a marker added very little to the detection rate above the maternal age alone. 1998 John Wiley & Sons, Ltd.

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✍ N. J. Wald; H. C. Watt; B. Norgaard-Pedersen; M. Christiansen 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB 👁 2 views

We conducted a study to determine the value of serum pregnancy-specific beta-1-glycoprotein (Schwangerschafts protein 1, SP1) as an antenatal screening test for Down syndrome in the first trimester. Serum samples collected from women at 8 to 14 weeks of pregnancy, immediately prior to having a chori