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Preliminary X-Ray Crystallographic and NMR Studies on the Exonuclease Domain of the ϵ Subunit of Escherichia coli DNA Polymerase III

✍ Scribed by Samir Hamdan; Susan E Brown; Phillip R Thompson; Ji Yeon Yang; Paul D Carr; David L Ollis; Gottfried Otting; Nicholas E Dixon


Book ID
115634144
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
227 KB
Volume
131
Category
Article
ISSN
1047-8477

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The subunit of DNA polymerase III, the main replicative polymerase of Escherichia coli, has been examined by circular dichroism and by NMR spectroscopy. The polymerase core consists of three subunits: ␣, ⑀, and , with ␣ possessing the polymerase activity, ⑀ functioning as a proofreading exonuclease,