Objective. To evaluate the influence of food on the bioavailability of an oral dose of methotrexate in patients with rheumatoid arthritis. Methods. Methotrexate (15 mg) was given intravenously and orally, with or without a meal, to 10 patients. Blood samples were drawn at specific intervals to eval
Preliminary experience with low-dose methotrexate in fibroblastic rheumatism
✍ Scribed by Olivier Vittecoq; Othmane Mejjad; Fernando Da Silva; Pascal Joly; Elizabeth Thomine; Philippe Lauret; Jean Michel Thomine; Xavier Le Loët
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 413 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## Objective To examine the long‐term efficacy of low‐dose intravenous methotrexate (MTX) with and without concomitant glucocorticoids (GC) for remission maintenance in patients with generalized Wegener's granulomatosis (WG) in an open‐label, prospective, standardized trial. ## Method
## BACKGROUND: Methotrexate is a proven teratogen and its use periconceptually is strongly advised against. Concerns about possible chromosomal effects in the offspring of women treated with this agent have been raised, but they have not been reported. In vivo and in vitro studies have supported t