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Preliminary Evaluation of the Major Protocol Variables for the Hershberger Castrated Male Rat Assay for the Detection of Androgens, Antiandrogens, and Metabolic Modulators

โœ Scribed by J. Ashby; P.A. Lefevre

Book ID
115646954
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
159 KB
Volume
31
Category
Article
ISSN
0273-2300

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The peripubertal male rat assay as an al
The peripubertal male rat assay as an alternative to the Hershberger castrated male rat assay for the detection of anti-androgens, oestrogens and metabolic modulators
โœ J. Ashby; P. A. Lefevre ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 142 KB

A range of chemicals with various levels of activity as actual or potential endocrine disrupters have been evaluated for activity in the peripubertal male rat assay. The chemicals studied included anti-androgens (vinclozolin), cyproterone acetate, flutamide, 2, 2-bis(4-chlorophenyl)-1,1-dichloroethy