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Preimplantation Genetic Diagnosis of Inherited Cancer: Familial Adenomatous Polyposis Coli

✍ Scribed by Asangla Ao; Dagan Wells; Alan H. Handyside; Robert M. L. Winston; Joy D. A. Delhanty


Book ID
110430719
Publisher
Springer US
Year
1998
Tongue
English
Weight
766 KB
Volume
15
Category
Article
ISSN
1573-7330

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Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T