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Pregnenolone sulfate block of GABAA receptors: mechanism and involvement of a residue in the M2 region of the α subunit

✍ Scribed by Gustav Akk; John Bracamontes; Joe Henry Steinbach

Book ID
111119895
Publisher
Cambridge University Press
Year
2001
Tongue
English
Weight
233 KB
Volume
532
Category
Article
ISSN
0022-3751

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The effects on the functional properties of the a 1 b 1 GABA A receptor when the 58 (a 1 Val260; b 1 Ile255) hydrophobic amino acids in the second transmembrane (M2) region were changed to threonine were examined. In response to a saturating concentration of GABA, the current evoked in mutant recept