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A threonine residue in the M2 region of the β1 subunit is needed for expression of functional α1β1 GABAA receptors

✍ Scribed by Julie E. Dalziel; Bryndis Birnir; Andrea B. Everitt; M.Louise Tierney; Graeme B. Cox; Peter W. Gage

Book ID
114017103
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
91 KB
Volume
370
Category
Article
ISSN
0014-2999

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Nature of the 5′ residue in the M2 domain affects function of the human α1β1 GABAA receptor
✍ B. Birnir; M.L. Tierney; M. Lim; G.B. Cox; P.W. Gage 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 50 KB 👁 1 views

The effects on the functional properties of the a 1 b 1 GABA A receptor when the 58 (a 1 Val260; b 1 Ile255) hydrophobic amino acids in the second transmembrane (M2) region were changed to threonine were examined. In response to a saturating concentration of GABA, the current evoked in mutant recept