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Prefrontal Serotonergic Denervation Induces Increase in the Density of 5-HT2AReceptors in Adult Rat Prefrontal Cortex

✍ Scribed by Cesar Soria-Fregozo; María Isabel Pérez-Vega; Ignacio González-Burgos; Alfredo Feria-Velasco; Carlos Beas-Zárate


Publisher
Springer
Year
2008
Tongue
English
Weight
322 KB
Volume
33
Category
Article
ISSN
0364-3190

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Rats received haloperidol (1.3-1.5 mg/kg/day) via their drinking water for 21 weeks. At the end of this period the density of D2 dopamine receptors and their affinity for [3H]-spiperone were measured in the striatum and medial prefrontal cortex. The chronic haloperidol treatment increased the densit