𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Preferential splenic metastases in parabiotic animals

✍ Scribed by Lionel Schour; Robert P. Faraci

Book ID
102438443
Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
338 KB
Volume
6
Category
Article
ISSN
0022-4790

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✦ Synopsis

Abstract

A reticulum cell sarconia which metastasizes preferentially to the spleens of inbred C~3~ H mice has been studied. Placement of tumor‐bearing animals in parabiosis with normal animals was followed by the development of gross metastases limited to the spleen in 100% of the normal animals. The pattern of metastases observed when a tumor‐bearing animal was placed in parabiosis with a splenectomized animal is described. The splenotrophic tendencies of this tumor and its ability to metastasize selectively across a parabiotic union provide a model for investigation of the role of immunity and humoral factors in tumor metastases.

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