The mortality rate from lung metastases in animals inhaling nitrogen dioxide (NO2)

✍ Scribed by Arnis Richters; Valda Richters; Wayne P. Alley

• Book ID: 102439479
• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 328 KB
• Volume: 28
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930280115

✦ Synopsis

A study was carried out to determine the interrelationship between the inhalation of nitrogen dioxide (0.4f 0.50 pprn), lung metastases development from circulating cancer cells, and death rate from such metastases. C57 BL/6J mice were used in these experiments. Animals were divided into control and NO2-exposed groups, and were exposed to filtered air and 0.4 ppm of NO2, respectively. Following 12 weeks of exposure, all animals were infused intravenously with syngeneic, viable B 16 melanoma cells. The results indicate that a subpopulation of N02-exposed animals showed a significant increase in mortality rate during the early part of the experiment. The interpretation is that animals especially sensitive to the NO2 insult developed extensive metastases at an early stage. The question raised is whether or not the progression of human cancer is influenced by the inhalation of noxious pollutants in the ambient atmosphere.