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Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain

✍ Scribed by Sharlyn J Mazur; Kazuyasu Sakaguchi; Ettore Appella; Xin Wei Wang; Curtis C Harris; Vilhelm A Bohr


Book ID
115629594
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
314 KB
Volume
292
Category
Article
ISSN
0022-2836

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## Abstract The __C__‐terminal domain of p53 comprises a linker, the tetramerization domain and the regulatory domain, and contains at least seven sites of potential post‐translational modification. An improved strategy was developed for the synthesis of large peptides that contain phosphorylated a