Predictors of response to exemestane as primary endocrine therapy in estrogen receptor–positive breast cancer
✍ Scribed by Hiroko Yamashita; Satoru Takahashi; Yukashi Ito; Toshinari Yamashita; Yoshiaki Ando; Tatsuya Toyama; Hiroshi Sugiura; Nobuyasu Yoshimoto; Shunzo Kobayashi; Yoshitaka Fujii; Hirotaka Iwase
- Book ID
- 108586466
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 324 KB
- Volume
- 100
- Category
- Article
- ISSN
- 1347-9032
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This review presents our experience with the use of estrogen receptors (ER) and progesterone receptors (PgR) in the prediction of response to endocrine therapy in stage IV breast cancer. Presence of ER (>3 fmoUmg cytosol protein) significantly predicted response to the antiestrogen tamoxifen and to
## Abstract ## BACKGROUND. Few studies have compared primary neoadjuvant endocrine therapy with neoadjuvant chemotherapy in breast cancer patients. The need for preoperative chemotherapy with doxorubicin or taxanes may be reduced in postmenopausal patients with estrogen receptor (ER)‐positive and/