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Estrogen receptors and response to endocrine therapy and cytotoxic chemotherapy in advanced breast cancer

✍ Scribed by R. D. Rubens; J. L. Hayward


Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
261 KB
Volume
46
Category
Article
ISSN
0008-543X

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We reviewed 89 patients with disseminated breast cancer who had at least one valid estrogen receptor (ER) assay and who underwent one or several trials of chemotherapy. The responses were assessed by two independent extramural reviewers. Of the 89 patients, 81 were evaluable; 28 of 36 (77.8%) ER-pos

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This review presents our experience with the use of estrogen receptors (ER) and progesterone receptors (PgR) in the prediction of response to endocrine therapy in stage IV breast cancer. Presence of ER (>3 fmoUmg cytosol protein) significantly predicted response to the antiestrogen tamoxifen and to