## The current study examines the neuroendocrine response to intravenous clomipramine (IV CMI) in oral CMI-resistant obsessive-compulsive disorder (OCD) patients on day 1 and day 14 of treatment to identify predictors of response. Forty-four OCD patients with an inadequate response or poorly toleran
Predictors of response to clozapine therapy
β Scribed by Gilbert Honigfeld; John Patin
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 324 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
β¦ Synopsis
Multiple regression analysis and discriminant function analyses were applied to the question of prediction of therapeutic success or failure to clozapine therapy, using a non-biological predictor pool of 46 items. This effort was not successful, accounting for less than 25% of outcome variance under optimal conditions. However, it does appear that while clozapine efficacy in treatment-resistant schizophrenic patients in general is superior to such neuroleptics as chlorpromazine or haloperidol, the "paranoid" subgroup appears to benifit most.
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