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Possible predictors of response to clonazepam augmentation therapy in patients with protracted depression

✍ Scribed by Shigeru Morishita; Seizaburo Arita

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 78 KB
Volume: 22
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.818

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Introduction

Clonazepam has been shown to be an effective supplementary treatment for depression. Thus, it would be useful to determine which patient characteristics are associated with response to clonazepam.

Aims

The purpose of this study was to examine the possible predictors of response to clonazepam in the treatment of depression.

Method

A retrospective cohort analysis was carried out in 120 patients with protracted depression who were being treated with clonazepam.

Results

A variety of clinical factors, including age, gender, type of depression, frequency of episodes, family history; and daily dose of clonazepam, were analyzed as possible predictors of response to clonazepam. A Weibull regression analysis showed that the factors that best predicted improvement with clonazepam augmentation were negative family history of psychiatric illness (e^coef^ = 0.378), daily clonazepam dose of 2.5–4.0 mg (e^coef^ = 0.160), and unipolar depression (e^coef^ = 0.147).

Conclusions

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