Response to ECT in depressed, demented patients; possible role of apolipoprotein E4 as response marker
✍ Scribed by Michael Fisman; Kiran Rabheru; Verinder Sharma
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 47 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0885-6230
- DOI
- 10.1002/gps.406
No coin nor oath required. For personal study only.
✦ Synopsis
Population based studies demonstrated that women with the smallest HC were 2.9 times more likely to have prevalent AD than the rest of the population (Scho®eld et al., 1997). Our ®nding of a significant association between HC and severity in a much smaller population suggests a particular susceptibility of some females with smaller brains to the cognitive decline associated with AD neurodegeneration. Gross premorbid brain volume, or perhaps some more spe-ci®c neurobiological factor, could provide a reserve against global intellectual decline in AD (Katzman et al., 1988).
Acknowledgements
This study was supported by CSO Grant No. K/RED/ 4/C312 from The Scottish Home and Health Department to MFS and RWP. The authors thank Kate Craig for making the vertebral canal measurements on vertebral MRI scans and also Professor Frank Smith for MRI scanning of patients and volunteers.
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