Background: Nonribosomal peptide synthetases (NRPSs) are large modular proteins that selectively bind, activate and condense amino acids in an ordered manner. Substrate recognition and activation occurs by reaction with ATP within the adenylation (A) domain of each module. Recently, the crystal stru
β¦ LIBER β¦
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
β Scribed by Gregory L Challis; Jacques Ravel; Craig A Townsend
- Book ID
- 108485908
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 443 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1074-5521
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## Abstract Precise theoretical predictions of NMR parameters are helpful for the spectroscopic identification of complicated biological molecules, especially for the carbon shielding tensors in amino acids. The ^13^C shielding tensors of various crystalline amino acids and peptides have been calcu