𝔖 Bobbio Scriptorium
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Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity

✍ Scribed by Dr. Jenny Thirlway; Dr. Richard Lewis; Laura Nunns; Dr. Majid Al Nakeeb; Matthew Styles; Dr. Anna-Winona Struck; Prof. Colin P. Smith; Prof. Jason Micklefield

Book ID
112001117
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
731 KB
Volume
51
Category
Article
ISSN
0044-8249

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✍ Gregory L Challis; Jacques Ravel; Craig A Townsend 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 443 KB

Background: Nonribosomal peptide synthetases (NRPSs) are large modular proteins that selectively bind, activate and condense amino acids in an ordered manner. Substrate recognition and activation occurs by reaction with ATP within the adenylation (A) domain of each module. Recently, the crystal stru