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Predictive and mechanistic toxicology of nanoparticulate carrier by hepatic gene expression profiling in the rat

✍ Scribed by Roger Kravtzoff; Odile Boutherin-Falson; Roy Forster; Sébastien Leuillet; Sandrine Arthaud; Philippe Ancian


Book ID
119380242
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
121 KB
Volume
180
Category
Article
ISSN
0378-4274

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✍ Masaharu Tada; Etsuro Hatano; Kojiro Taura; Takashi Nitta; Naoki Koizumi; Iwao I 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 447 KB

## Abstract ## Background Hydrodynamic injection of naked plasmid DNA (pDNA) via the tail vein is a safe and effective method of gene transfer to the liver. However, successful gene transfer has yet to be shown for hepatocellular carcinoma (HCC); therefore, we investigated the feasibility and effi