Collagen gene expression in hepatic fibrosis: mRNA levels of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine (DMN) in the rat
β Scribed by Sporns, Peter
- Book ID
- 121975334
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 74 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0168-8278
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Cirrhosis is characterized by a marked increase in the deposition of type I collagen and in the expression of the type I collagen genes d ( 1 ) and &(I). Although al(1) gene regulation has been extensively studied in cultured cells, these results may not be applicable to hepatic fibrogenesis in uiuo
Liver fibrosis was induced in rats both with carbon tetrachloride and dimethylnitrosamine. Assays were performed on steady-state levels of messenger RNAs in the liver for several collagens and basement membrane components. The results indicated marked increases in the steady-state levels of messenge