Tissue:plasma (P(t:p)) partition coefficients (PCs) are important parameters describing tissue distribution of drugs. The ultimate goal in early drug discovery is to develop and validate in silico methods for predicting a priori the P(t:p) for each new drug candidate. In this context, tissue composi
Prediction of the volume of distribution of a drug: which tissue-plasma partition coefficients are needed?
✍ Scribed by Sven Björkman
- Book ID
- 111769128
- Publisher
- Pharmaceutical Press
- Year
- 2002
- Tongue
- English
- Weight
- 214 KB
- Volume
- 54
- Category
- Article
- ISSN
- 2042-7158
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📜 SIMILAR VOLUMES
The tissue:plasma (P t:p ) partition coefficients (PCs) are important drugspecific input parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the disposition of drugs in biota. Until now the use of PBPK models in early stages of the drug discovery process was not possib
One of the drug specific parameters needed in physiologically based pharmacokinetic (PBPK) models is the tissue to plasma drug concentration ratios (K(p) values). The aim of this study was to develop an empirical method for predicting K(p) values using a preclinically determined in vivo volume of di