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A simulation model for the prediction of tissue:plasma partition coefficients for drug residues in natural casings

✍ Scribed by Aneliya Milanova Haritova; Johanna Fink-Gremmels


Book ID
113939659
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
358 KB
Volume
185
Category
Article
ISSN
1090-0233

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A priori prediction of tissue:plasma par
✍ Patrick Poulin; Frank-Peter Theil πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 374 KB πŸ‘ 3 views

The tissue:plasma (P t:p ) partition coefficients (PCs) are important drugspecific input parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the disposition of drugs in biota. Until now the use of PBPK models in early stages of the drug discovery process was not possib