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Prediction of the pharmacokinetics of succinylated human serum albumin in man from in vivo disposition data in animals and in vitro liver slice incubations

✍ Scribed by Johannes H. Proost; Leonie Beljaars; Peter Olinga; Pieter J. Swart; Mirjam E. Kuipers; Catharina Reker-Smit; Geny M.M. Groothuis; Dirk K.F. Meijer


Book ID
113591565
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
329 KB
Volume
27
Category
Article
ISSN
0928-0987

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Prediction of the volume of distribution
✍ W. A. Ritschel; R. D. Johnson; N. N. Vachharajani; A. S. Hussain πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 661 KB

## Abstract The essential parameter to estimate the first dose size of a drug in man is the volume of distribution. For a drug that has never been used in man before, estimates of the volume of distribution can only be obtained from animals and __in vitro__ data. The purpose of this study was to co