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Bosentan, a new endothelin receptor antagonist: prediction of the systemic plasma clearance in man from combined in vivo and in vitro data

โœ Scribed by Ubeaud, G.; Schmitt, C.; Jaeck, D.; Lave, T.; Coassolo, Ph.


Book ID
120576782
Publisher
Informa plc
Year
1995
Tongue
English
Weight
696 KB
Volume
25
Category
Article
ISSN
0049-8254

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Prediction of the volume of distribution
โœ W. A. Ritschel; R. D. Johnson; N. N. Vachharajani; A. S. Hussain ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 661 KB

## Abstract The essential parameter to estimate the first dose size of a drug in man is the volume of distribution. For a drug that has never been used in man before, estimates of the volume of distribution can only be obtained from animals and __in vitro__ data. The purpose of this study was to co