One of the drug specific parameters needed in physiologically based pharmacokinetic (PBPK) models is the tissue to plasma drug concentration ratios (K(p) values). The aim of this study was to develop an empirical method for predicting K(p) values using a preclinically determined in vivo volume of di
Prediction of human blood-to-plasma drug concentration ratio
β Scribed by Takahide Uchimura; Motohiro Kato; Tomohisa Saito; Haruki Kinoshita
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 260 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.711
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