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Prediction of Human Blood: Air Partition Coefficient: A Comparison of Structure-Based and Property-Based Methods

✍ Scribed by Subhash C. Basak; Denise Mills; Douglas M. Hawkins; Hisham A. El-Masri


Book ID
110749189
Publisher
Springer
Year
2003
Tongue
English
Weight
123 KB
Volume
23
Category
Article
ISSN
1573-9147

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Partitioning of up to thirty-six nonionizable chemicals between seven tissues (fat, liver, brain, kidney, muscle, lung, heart) and blood in humans was modeled using membrane accumulation, protein binding, and distribution in the aqueous phases as relevant processes. The extent of membrane accumulati