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A Tissue Composition-Based Algorithm for Predicting Tissue:Air Partition Coefficients of Organic Chemicals

✍ Scribed by Patrick Poulin; Kannan Krishnan

Book ID
112266006
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
63 KB
Volume
136
Category
Article
ISSN
0041-008X

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Partitioning of up to thirty-six nonionizable chemicals between seven tissues (fat, liver, brain, kidney, muscle, lung, heart) and blood in humans was modeled using membrane accumulation, protein binding, and distribution in the aqueous phases as relevant processes. The extent of membrane accumulati