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Prediction of food effects on the absorption of celecoxib based on biorelevant dissolution testing coupled with physiologically based pharmacokinetic modeling

โœ Scribed by Yasushi Shono; Ekarat Jantratid; Niels Janssen; Filippos Kesisoglou; Yun Mao; Maria Vertzoni; Christos Reppas; Jennifer B. Dressman


Book ID
116438202
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
484 KB
Volume
73
Category
Article
ISSN
0939-6411

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Using a novel multicompartment dissoluti
โœ Gu, Chong Hui (author);Rao, Deepa (author);Gandhi, Rajesh B. (author);Hilden, Jo ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons Inc. ๐ŸŒ English โš– 269 KB

A novel multicompartment dissolution system was developed by modifying a conventional six-vessel United States Pharmacopoeia dissolution system to study the dissolution and possible precipitation of poorly soluble weak bases after oral administration. The modified system includes a ''gastric '' comp