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Using a novel multicompartment dissolution system to predict the effect of gastric pH on the oral absorption of weak bases with poor intrinsic solubility

โœ Scribed by Gu, Chong Hui (author);Rao, Deepa (author);Gandhi, Rajesh B. (author);Hilden, Jon (author);Raghavan, Krishnaswamy (author)

Publisher
John Wiley and Sons Inc.
Year
2005
Tongue
English
Weight
269 KB
Volume
94
Category
Article
ISSN
0022-3549

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Using a novel multicompartment dissoluti
Using a novel multicompartment dissolution system to predict the effect of gastric pH on the oral absorption of weak bases with poor intrinsic solubility
โœ Gu, Chong Hui (author);Rao, Deepa (author);Gandhi, Rajesh B. (author);Hilden, Jo ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons Inc. ๐ŸŒ English โš– 269 KB

A novel multicompartment dissolution system was developed by modifying a conventional six-vessel United States Pharmacopoeia dissolution system to study the dissolution and possible precipitation of poorly soluble weak bases after oral administration. The modified system includes a ''gastric '' comp