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Prediction of drug concentration-time data in humans from animals: a comparison of three methods

✍ Scribed by Mahmood, Iftekhar; Goteti, Kosalaram

Book ID
115544878
Publisher
Informa plc
Year
2012
Tongue
English
Weight
950 KB
Volume
42
Category
Article
ISSN
0049-8254

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πŸ“œ SIMILAR VOLUMES

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Prediction of human drug clearance from two species: A comparison of several allometric methods
✍ Kosalaram Goteti; C. Edwin Garner; Iftekhar Mahmood πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 147 KB

The objective of the study was to assess the degree of accuracy in human drug clearance prediction from two species using four different allometric approaches: simple allometry (SA), multiexponential allometry (ME), rule of exponents (ROE), and fixed exponents (FE) as suggested by Tang et al. There

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✍ Iftekhar Mahmood πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 145 KB

The objective of this study is to evaluate the predictive performance of the rule of exponents (ROE) and 'fu Corrected Intercept Method' (FCIM) for the human drug clearance. Different classes of drugs such as extensively metabolized, renally excreted, renally secreted, and biliary excreted drugs wer