Prediction of breast cancer prognosis by gene expression profile of TP53 status
β Scribed by Shin Takahashi; Takuya Moriya; Takanori Ishida; Hiroyuki Shibata; Hironobu Sasano; Noriaki Ohuchi; Chikashi Ishioka
- Book ID
- 108584085
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 708 KB
- Volume
- 99
- Category
- Article
- ISSN
- 1347-9032
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We intended to establish the frequency of exon-specific TP53 gene alterations and the relation t o patient and tumor characteristics and clinical outcome of patients with breast cancer. By using polymerase chain reaction-single-strand conformation polymorphism analysis (KR-SSCP) and sequencing techn
## Abstract Promising results for prediction of outcome in breast cancer have been obtained by genome wide gene expression profiling. Some studies have suggested that an extensive overtreatment of breast cancer patients might be reduced by risk assessment with gene expression profiling. A patient g