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Prediction for the Separation Efficiency of a Pair of Enantiomers during Chiral High-Performance Liquid Chromatography Using a Quartz Crystal Microbalance

✍ Scribed by Inagaki, Shinsuke; Min, Jun Zhe; Toyo'oka, Toshimasa


Book ID
118025761
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
157 KB
Volume
80
Category
Article
ISSN
0003-2700

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A procedure is described which allows the on-line recovery of enantiomers following semi-preparative chiral separation by RP-HPLC using beta-cyclodextrin in the mobile phase. By this method, the phenothiazine antihistamine trimeprazine (I) was resolved into its antipodes at greater than 95% optical